Pediatrics II Please enable JavaScript in your browser to complete this form.Please enable JavaScript in your browser to complete this form.Question 2)The radiographs are of a 1-year-old girl who underwent bilateral reconstructive surgery for a similar bilateral hand deformity. During embryogenesis, there was a problem with control of the anteroposterior (AP) axis (thumb to small finger, great toe to small toe) in all of her developing limb buds. The AP axis, which is under the control of an area of tissue in the posterior aspect of the apical ectodermal ridge, is known as the Select the Correct Answerarea for preaxial focus (APF).area of digital specfification (ADS)zone of polarizing activity (ZPA).zone of axial determination (ZAD).sonic hedgehog zone (SHH).Correct Answer: zone of polarizing activity (ZPA) Explanation: The ZPA controls the posterior aspect of the apical ectodermal ridge. There is no APF, ADS, or ZAD to control the apical ectodermal ridge. There is a sonic hedgehog gene, but no zone. The sonic hedgehog gene is expressed in the ZPA. Reference: Source 2015 OITE Herring JA. Disorders of the upper extremity. In: Herring JA, ed. Tachdjian’s Pediatric Orthopaedics, 3rd ed. Philadelphia, PA: WB Saunders; 2002:379-512. Waters PM. The upper limb. In: Morrissy RT, Weinstein SL, eds. Lovell and Winter’s Pediatric Orthopaedics. 6th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2006:921-98 Wrong Answer: Please try again! Submit Post navigation Previous QuestionPediatrics INext QuestionPediatrics III